Journal article
Immunotherapies for Immune-Mediated myopathies: A current perspective
Neurotherapeutics, Vol.13(1), pp.132-146
2015
Abstract
Until recently, the treatment of immune-mediated inflammatory myopathies has largely been empirical with glucocorticoids, steroid-sparing immunosuppressive drugs, and intravenous immunoglobulin. However, a proportion of patients are only partially responsive to these therapies, and there has been a need to consider alternative treatment approaches. In particular, patients with inclusion body myositis are resistant to conventional immunotherapies or show only a transient response, and remain a major challenge. With increasing recognition of the different subtypes of immune-mediated inflammatory myopathies, and improved understanding of their pathogenesis, more targeted treatments are now being trialled. The overall approach to treatment, and novel therapies targeting B cells, T cells, and specific cytokines are discussed in this review.
Details
- Title
- Immunotherapies for Immune-Mediated myopathies: A current perspective
- Authors/Creators
- M. Needham (Author/Creator) - Fiona Stanley HospitalF.L. Mastaglia (Author/Creator) - Murdoch University
- Publication Details
- Neurotherapeutics, Vol.13(1), pp.132-146
- Publisher
- Springer US
- Identifiers
- 991005540100107891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- ESI research areas
- Neuroscience & Behavior