Journal article
Impact of African herbal medicines on antiretroviral metabolism
AIDS, Vol.19(1), pp.95-97
2005
Abstract
We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.
Details
- Title
- Impact of African herbal medicines on antiretroviral metabolism
- Authors/Creators
- E. Mills (Author/Creator)B.C. Foster (Author/Creator)R.P.G. van Heeswijk (Author/Creator)E. Phillips (Author/Creator)K. Wilson (Author/Creator)B. Leonard (Author/Creator)K. Kosuge (Author/Creator)I. Kanfer (Author/Creator)
- Publication Details
- AIDS, Vol.19(1), pp.95-97
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005546348007891
- Copyright
- © 2005 Lippincott Williams & Wilkins, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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