Journal article
Impact of conventional breath inspiratory time during high-frequency jet ventilation in preterm lambs
Neonatology, Vol.101(4), pp.267-273
2012
Abstract
Background: Conventional mechanical ventilator (CMV) breaths during high-frequency jet ventilation (HFJV) are advocated to recruit and stabilize alveoli. Objectives: To establish if CMV breath duration delivered during HFJV influences gas exchange, lung mechanics and lung injury. Methods: Preterm lambs at 128 days gestational age were studied. HFJV (7 Hz, PEEP 8 cm H2O, PIPHFJV 40 cm H2O, FiO2 0.4) with superimposed CMV breaths (PIPCMV 25 cm H2O, rate 5 breaths/min) was commenced after delivery and continued for 2 h. CMV breath inspiratory time (tI) was either 0.5 s (HFJV+CMV0.5; n = 8) or 2.0 s (HFJV+CMV2.0; n = 8). Age-matched unventilated controls (UVC) were included for comparison. Results: Serial arterial blood gas analyses were performed. PIPHFJV was adjusted to target a PaCO2 of 45–55 mm Hg. FiO2 was adjusted to target SpO2 90–95%. Pressure-volume curves, broncho-alveolar lavage (BAL) and lung tissue samples were obtained postmortem. Gas exchange, ventilation parameters, static lung compliance and BAL inflammatory markers were not different between HFJV+CMV0.5 and HFJV+CMV2.0. Both ventilation groups had higher BAL inflammatory markers and increased iNOS-positive cells on histology compared to UVC, whilst lung tissue IL-1β and IL-6 mRNA expression was higher in the HFJV+CMV2.0 group compared to the UVC group. Conclusions: Preterm lambs were ventilated effectively with HFJV and 5 CMV breaths/min. CMV breath duration did not alter blood gas exchange, ventilation parameters, ex vivo static lung mechanics or markers of lung injury over a 2-hour study, although consistent trends towards increased inflammatory markers with the longer tI suggest greater risk of injury.
Details
- Title
- Impact of conventional breath inspiratory time during high-frequency jet ventilation in preterm lambs
- Authors/Creators
- G.C. Musk (Author/Creator)G.R. Polglase (Author/Creator)Y. Song (Author/Creator)J.J. Pillow (Author/Creator)
- Publication Details
- Neonatology, Vol.101(4), pp.267-273
- Identifiers
- 991005545394507891
- Copyright
- © 2012 S. Karger AG, Basel
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1057 Pulmonary Surfactant
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine