Journal article
Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse
Histochemistry and Cell Biology, Vol.144(4), pp.389-402
2015
Abstract
The widely used diethylhexyl phthalate (DEHP) is a known endocrine disruptor that causes persistent alterations in the structure and function of female reproductive system, including ovaries, uterus and oviducts. To explore the molecular mechanism of the effect of DEHP on the development of mammary glands, we investigated the cell cycle, growth, proliferation and gene expression of mammary gland cells of pregnant mice exposed to DEHP. It was demonstrated, for the first time, that the mammary gland cells of pregnant mice treated with DEHP for 0.5–3.5 days post-coitum had increased proliferation, growth rate and number of cells in the G2/S phase. The expression of cell proliferation-related genes was significantly altered after short time and low-dose DEHP treatment of mammary gland cells in vivo and in vitro. These findings showed adverse effects of DEHP on mammary gland cells in pregnant mice.
Details
- Title
- Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse
- Authors/Creators
- L. Li (Author/Creator)J-C Liu (Author/Creator)Y. Zhao (Author/Creator)F-N Lai (Author/Creator)F. Yang (Author/Creator)W. Ge (Author/Creator)C-L Dou (Author/Creator)W. Shen (Author/Creator)X-F Zhang (Author/Creator)H. Chen (Author/Creator)
- Publication Details
- Histochemistry and Cell Biology, Vol.144(4), pp.389-402
- Publisher
- Springer Verlag
- Identifiers
- 991005543428507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.60 Herbicides, Pesticides & Ground Poisoning
- 3.60.1654 Phthalates
- Web Of Science research areas
- Cell Biology
- Microscopy
- ESI research areas
- Biology & Biochemistry