Journal article
Improved cardiovascular tolerance to hemorrhage after oral resveratrol pretreatment in dogs
Veterinary Sciences, Vol.8(7), Article 129
2021
Abstract
Resveratrol has been shown to preserve organ function and improve survival in hemorrhagic shock rat models. This study investigated whether seven days of oral resveratrol could improve hemodynamic response to hemorrhage and confer benefits on risk of acute kidney injury (AKI) without inducing coagulopathy in a canine model. Twelve greyhound dogs were randomly allocated to receive oral resveratrol (1000 mg/day) or placebo for seven days prior to inducing hemorrhage until a targeted mean blood pressure of ≤40 mmHg was achieved. AKI biomarkers and coagulation parameters were measured before, immediately following, and two hours after hemorrhage. Dogs were euthanized, and renal tissues were examined at the end of the experiment. All investigators were blinded to the treatment allocation. A linear mixed model was used to assess effect of resveratrol on AKI biomarkers and coagulation parameters while adjusting for volume of blood loss. A significant larger volume of blood loss was required to achieve the hypotension target in the resveratrol group compared to placebo group (median 64 vs. 55 mL/kg respectively, p = 0.041). Although histological evidence of AKI was evident in all dogs, the renal tubular injury scores were not significantly different between the two groups, neither were the AKI biomarkers. Baseline (pre-hemorrhage) maximum clot firmness on the Rotational Thromboelastometry (ROTEM®) was stronger in the resveratrol group than the placebo group (median 54 vs. 43 mm respectively, p = 0.009). In summary, seven days of oral resveratrol did not appear to induce increased bleeding risk and could improve greyhound dogs’ blood pressure tolerance to severe hemorrhage. Renal protective effect of resveratrol was, however, not observed.
Details
- Title
- Improved cardiovascular tolerance to hemorrhage after oral resveratrol pretreatment in dogs
- Authors/Creators
- J. Davis (Author/Creator) - Murdoch UniversityA.L. Raisis (Author/Creator) - Murdoch UniversityC.R. Sharp (Author/Creator) - Murdoch UniversityR.E. Cianciolo (Author/Creator) - The Ohio State UniversityS.C. Wallis (Author/Creator) - The University of QueenslandK.M. Ho (Author/Creator) - Murdoch University
- Publication Details
- Veterinary Sciences, Vol.8(7), Article 129
- Publisher
- MDPI
- Identifiers
- 991005542103207891
- Copyright
- © 2021 by the authors
- Murdoch Affiliation
- School of Veterinary Medicine; Centre for Climate-Impacted Terrestrial Ecosystems; Harry Butler Institute
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
68 File views/ downloads
67 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.830 Acute Kidney Injury
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science