Journal article
In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development
Pediatric Allergy and Immunology
2020
Abstract
Background
Low vitamin D levels have been associated with allergic diseases. Vitamin D has potent immunomodulatory properties, but the mechanisms remain unclear. We have investigated the effect of oral vitamin D supplementation on circulating immune cell phenotypes in infants.
Method
A double‐blinded randomised controlled trial was conducted to investigate the effect of oral vitamin D supplementation (400 IU/d) on eczema and immune development. A subset of 78 infants was included in this analysis. Phenotypic analysis of immune cell subsets was performed using flow cytometry.
Results
Vitamin D supplementation resulted in median 25(OH)D levels of 80.5 vs 59.5 nmol/L in the placebo group at 3 months of age (P = .002) and 87.5 vs 77 nmol/L at 6 months of age (P = .08). We observed significant changes in immune cell composition from birth (cord blood) to 6 months of age. Vitamin D supplementation did not impact these changes, nor did immune cell composition correlate with plasma 25(OH)D levels. Through exploratory analysis, we identified possible associations with eczema development and increased abundance of naïve CD4‐ T cells at birth, as well as associations with basophils, iNKT and central memory CD4+ T cells, and altered expression patterns of IgE receptor (FcεR1) on monocytes and dendritic cells with eczema at 6 months.
Conclusions
Vitamin D supplementation in infants who were vitamin D sufficient at birth did not affect developmental changes in immune cells during the first 6 months of life. However, immune cell profiles at birth and at 6 months of age were associated with early life eczema.
Details
- Title
- In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development
- Authors/Creators
- J. Leffler (Author/Creator) - The Kids Research Institute AustraliaC. Gamez (Author/Creator) - The Kids Research Institute AustraliaA.P. Jones (Author/Creator) - The Kids Research Institute AustraliaK. Rueter (Author/Creator) - Princess Margaret Hospital for ChildrenJ.F. Read (Author/Creator) - The Kids Research Institute AustraliaA. Siafarikas (Author/Creator) - The Kids Research Institute AustraliaE‐M. Lim (Author/Creator)P.S. Noakes (Author/Creator) - The University of Notre Dame AustraliaS.L. Prescott (Author/Creator) - Princess Margaret Hospital for ChildrenP.A. Stumbles (Author/Creator) - Murdoch UniversityD.J. Palmer (Author/Creator) - The Kids Research Institute AustraliaD.H. Strickland (Author/Creator) - The Kids Research Institute AustraliaA. Santos (Author/Creator)
- Publication Details
- Pediatric Allergy and Immunology
- Publisher
- John Wiley and Sons Ltd.
- Identifiers
- 991005540098507891
- Copyright
- © 2020 EAACI and John Wiley and Sons A/S.
- Murdoch Affiliation
- College of Science, Health, Engineering and Education
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.80 Bone Diseases
- 1.80.279 Vitamin D
- Web Of Science research areas
- Allergy
- Immunology
- Pediatrics
- ESI research areas
- Immunology