Journal article
In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics
Gene, Vol.312, pp.257-261
2003
Abstract
Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs.
Details
- Title
- In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics
- Authors/Creators
- N. Longman-Jacobsen (Author/Creator)J.F. Williamson (Author/Creator)R.L. Dawkins (Author/Creator)S. Gaudieri (Author/Creator)
- Publication Details
- Gene, Vol.312, pp.257-261
- Publisher
- Elsevier BV
- Identifiers
- 991005544848907891
- Copyright
- © Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics