In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites

S.H. Chin Lee; R. Jefferies; P. Watt; R.M. Hopkins; F. Sotzik; S. Reid; A. Armson; A. Boxell; U. Ryan

doi:10.1016/j.exppara.2007.08.019

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In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites

Journal article

Peer reviewed

In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites

S.H. Chin Lee, R. Jefferies, P. Watt, R.M. Hopkins, F. Sotzik, S. Reid, A. Armson, A. Boxell and U. Ryan

Experimental Parasitology, Vol.118(3), pp.303-307

2008

DOI: https://doi.org/10.1016/j.exppara.2007.08.019

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Abstract

The present study was undertaken to analyse the capability of HIV-1 derived TAT protein transduction domain (PTD) fused with Green Fluorescent Protein (TAT-GFP) as a delivery vehicle into a range of protozoan parasites. Successful transduction of native purified TAT-GFP was observed by fluorescent microscopy in Cryptosporidium parvum, Giardia duodenalis, and Neospora caninum. The ability to transduce peptides and other cargo into protozoan parasites, will greatly assist in the delivery of future peptide-based drugs and target validation peptides.

Details

Title: In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites
Authors/Creators: S.H. Chin Lee (Author/Creator)
R. Jefferies (Author/Creator) - The Kids Research Institute Australia
P. Watt (Author/Creator) - The Kids Research Institute Australia
R.M. Hopkins (Author/Creator)
F. Sotzik (Author/Creator) - The Kids Research Institute Australia
S. Reid (Author/Creator) - Murdoch University
A. Armson (Author/Creator) - Murdoch University
A. Boxell (Author/Creator) - Murdoch University
U. Ryan (Author/Creator) - Murdoch University
Publication Details: Experimental Parasitology, Vol.118(3), pp.303-307
Publisher: Academic Press
Identifiers: 991005544520607891
Copyright: © 2007 Elsevier Inc.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences; School of Nursing and Midwifery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 2 Chemistry; 2.53 Polymers & Macromolecules; 2.53.70 Nanocarrier Drug Delivery
Web Of Science research areas: Parasitology
ESI research areas: Microbiology