In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus

R.C.A. Thompson; J.A. Reynoldson; B.R. Manger

doi:10.1016/0034-5288(91)90087-5

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In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus

Journal article

Peer reviewed

In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus

R.C.A. Thompson, J.A. Reynoldson and B.R. Manger

Research in Veterinary Sciench, Vol.51(3), pp.332-334

1991

DOI: https://doi.org/10.1016/0034-5288(91)90087-5

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Abstract

In vitro, epsiprantel at a concentration of 10 μg ml−1 caused tegumental damage and death of protoscoleces, juveniles (seven-day-old) and adult (37-day-old) Echinococcus granulosus. Degenerative changes and death occurred more rapidly in the older parasites. Similarly, epsiprantel was more effective against adult (28-day-old) than seven-day-old experimental infections of E granulosus in dogs. Oral doses of 2·5, 5 and 7·5 mg kg−1 were greater than 96 per cent, 99·9 per cent and 99·99 per cent active, respectively, against mature worms, whereas in seven-day-old infections doses of 5, 7·5 and 10 mg kg−1 produced greater than 94 per cent, 90 per cent and 99·8 per cent reduction in worm burdens, respectively. No side effects from treatment were seen.

Details

Title: In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus
Authors/Creators: R.C.A. Thompson (Author/Creator) - Murdoch University
J.A. Reynoldson (Author/Creator) - Murdoch University
B.R. Manger (Author/Creator) - SmithKline Beecham Animal Health
Publication Details: Research in Veterinary Sciench, Vol.51(3), pp.332-334
Publisher: W. B. Saunders Co., Ltd.
Identifiers: 991005540695207891
Copyright: © 1991 Published by Elsevier Ltd.
Murdoch Affiliation: School of Veterinary Studies
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1106 Echinococcosis
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science