In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus

Anne A Wooldridge; Susan C Eades; Giselle L Hosgood; Rustin M Moore

doi:10.2460/ajvr.2002.63.1732

Back

In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus

Journal article

Open access

Peer reviewed

In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus

Anne A Wooldridge, Susan C Eades, Giselle L Hosgood and Rustin M Moore

American journal of veterinary research, Vol.63(12), pp.1732-1737

2002

DOI: https://doi.org/10.2460/ajvr.2002.63.1732

PMID: 12492290

Files and links (1)

pdf

Published181.55 kBDownload View

Published (Version of Record)CC BY-NC V4.0, Open Access

Abstract

Objective To characterize the in vitro effects of oxytocin, acepromazine, xylazine, butorphanol, detomidine, dantrolene, isoproterenol, and terbutaline on skeletal and smooth muscle from the equine esophagus. Animals 14 adult horses without digestive tract disease. Procedure Circular and longitudinal strips from the skeletal and smooth muscle of the esophagus were suspended in tissue baths, connected to force-displacement transducers interfaced with a physiograph, and electrical field stimulation was applied. Cumulative concentration-response curves were generated for oxytocin, acepromazine, xylazine, detomidine, butorphanol, isoproterenol, terbutaline, and dantrolene. Mean maximum twitch amplitude for 3 contractions/min was recorded and compared with predrug-vehicle values for the skeletal muscle segments, and area under the curve (AUC) for 3 contractions/min was compared with predrug-vehicle values for the smooth muscle segments. Results No drugs caused a significant change in skeletal muscle response. In smooth muscle, isoproterenol, terbutaline, and oxytocin significantly reduced AUC in a concentration-dependent manner. Maximum reduction in AUC was 69% at 10–4M for isoproterenol, 63% at 10–5M for terbutaline, and 64% at 10–4M for oxytocin. Conclusions and Clinical Relevance Isoproterenol, terbutaline, and oxytocin cause relaxation of the smooth muscle portion of the esophagus. The clinical relaxant effects on the proximal portion of the esophagus reported of drugs such as oxytocin, detomidine, and acepromazine may be the result of centrally mediated mechanisms.

Details

Title: In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus
Authors/Creators: Anne A Wooldridge
Susan C Eades
Giselle L Hosgood
Rustin M Moore
Publication Details: American journal of veterinary research, Vol.63(12), pp.1732-1737
Identifiers: 991005592769307891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

17 File views/ downloads

83 Record Views

12 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.232 Veterinary Sciences; 3.232.1936 Equine and Bovine Gastrointestinal Disorders
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science