Journal article
In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages
Nature Medicine, Vol.25(11), pp.1699-1705
2019
Abstract
Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage embryogenesis following in vitro fertilization (IVF)1,2,3, its rate in naturally conceived human embryos is unknown. CIN leads to mosaic embryos that contain a combination of genetically normal and abnormal cells, and is significantly higher in in vitro-produced preimplantation embryos as compared to in vivo-conceived preimplantation embryos4. Even though embryos with CIN-derived complex aneuploidies may arrest between the cleavage and blastocyst stages of embryogenesis5,6, a high number of embryos containing abnormal cells can pass this strong selection barrier7,8. However, neither the prevalence nor extent of CIN during prenatal development and at birth, following IVF treatment, is well understood. Here we profiled the genomic landscape of fetal and placental tissues postpartum from both IVF and naturally conceived children, to investigate the prevalence and persistence of large genetic aberrations that probably arose from IVF-related CIN. We demonstrate that CIN is not preserved at later stages of prenatal development, and that de novo numerical aberrations or large structural DNA imbalances occur at similar rates in IVF and naturally conceived live-born neonates. Our findings affirm that human IVF treatment has no detrimental effect on the chromosomal constitution of fetal and placental lineages.
Details
- Title
- In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages
- Authors/Creators
- M. Zamani Esteki (Author/Creator)T. Viltrop (Author/Creator)O. Tšuiko (Author/Creator)A. Tiirats (Author/Creator)M. Koel (Author/Creator)M. Nõukas (Author/Creator)O. Žilina (Author/Creator)K. Teearu (Author/Creator)H. Marjonen (Author/Creator)H. Kahila (Author/Creator)J. Meekels (Author/Creator)V. Söderström-Anttila (Author/Creator)A-M Suikkari (Author/Creator)A. Tiitinen (Author/Creator)R. Mägi (Author/Creator)S. Kõks (Author/Creator)N. Kaminen-Ahola (Author/Creator)A. Kurg (Author/Creator)T. Voet (Author/Creator)J.R. Vermeesch (Author/Creator)A. Salumets (Author/Creator)
- Publication Details
- Nature Medicine, Vol.25(11), pp.1699-1705
- Publisher
- Nature Publishing Group
- Identifiers
- 991005544909907891
- Copyright
- © 2019 Springer Nature Limited
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.339 Embryo Development
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental
- ESI research areas
- Molecular Biology & Genetics