Journal article
In vivo efficacy of albendazole againstGiardia duodenalis in mice
Parasitology Research, Vol.77(4), pp.325-328
1991
Abstract
The antigiardial effects of albendazole were demonstrated in vivo using experimental infections ofGiardia duodenalis in mice. These results complement previous in vivo studies in which albendazole was shown to have more potent antigiardial action than the currently applied antigiardial drugs. In mice, 2–4 doses (>100 mg/kg twice daily) were required for complete inhibition of cyst excretion and full elimination of trophozoites from the small intestine. The high doses necessary in mice were not unexpected and are discussed in light of the possible pharmacokinetics of albendazole in the animal model used in this study.
Details
- Title
- In vivo efficacy of albendazole againstGiardia duodenalis in mice
- Authors/Creators
- J.A. Reynoldson (Author/Creator) - Murdoch UniversityR.C.A. Thompson (Author/Creator) - Murdoch UniversityB.P. Meloni (Author/Creator) - Murdoch University
- Publication Details
- Parasitology Research, Vol.77(4), pp.325-328
- Publisher
- Springer Verlag
- Identifiers
- 991005546330207891
- Copyright
- © 1991 Springer-Verlag.
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology