In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

M. Desport; I.W.M. Tenaya; A. McLachlan; T.J. McNab; J. Rachmat; N. Hartaningsih; G.E. Wilcox

doi:10.1016/j.virol.2009.07.027

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In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

Journal article

Peer reviewed

In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

M. Desport, I.W.M. Tenaya, A. McLachlan, T.J. McNab, J. Rachmat, N. Hartaningsih and G.E. Wilcox

Virology, Vol.393(2), pp.221-227

2009

DOI: https://doi.org/10.1016/j.virol.2009.07.027

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Abstract

Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.

Details

Title: In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection
Authors/Creators: M. Desport (Author/Creator)
I.W.M. Tenaya (Author/Creator)
A. McLachlan (Author/Creator)
T.J. McNab (Author/Creator)
J. Rachmat (Author/Creator)
N. Hartaningsih (Author/Creator)
G.E. Wilcox (Author/Creator)
Publication Details: Virology, Vol.393(2), pp.221-227
Publisher: Elsevier
Identifiers: 991005541753407891
Copyright: © 2009 Elsevier Inc.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Virology
ESI research areas: Microbiology