Journal article
In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection
Virology, Vol.393(2), pp.221-227
2009
Abstract
Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.
Details
- Title
- In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection
- Authors/Creators
- M. Desport (Author/Creator)I.W.M. Tenaya (Author/Creator)A. McLachlan (Author/Creator)T.J. McNab (Author/Creator)J. Rachmat (Author/Creator)N. Hartaningsih (Author/Creator)G.E. Wilcox (Author/Creator)
- Publication Details
- Virology, Vol.393(2), pp.221-227
- Publisher
- Elsevier
- Identifiers
- 991005541753407891
- Copyright
- © 2009 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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