Journal article
Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India
Journal of Medical Genetics, Vol.24(6), pp.362-365
1987
Abstract
Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool.
Details
- Title
- Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India
- Authors/Creators
- A.R. Devi (Author/Creator)N.A. Rao (Author/Creator)A.H. Bittles (Author/Creator)
- Publication Details
- Journal of Medical Genetics, Vol.24(6), pp.362-365
- Publisher
- BMJ Group
- Identifiers
- 991005545171607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.189 Genome Studies
- 1.189.1853 Human Genetic Diversity
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Clinical Medicine