Journal article
Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography
Journal of Veterinary Emergency and Critical Care, Vol.22(2), pp.262-266
2012
Abstract
Objective - To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography.
Design - Retrospective clinical case study.
Setting - University veterinary teaching hospital.
Animals - Sixty-six dogs (mixed and pure breeds), aged between 4 months and 15 years, weighing between 3.5-61 kg. All animals were classified as ASA score I or II.
Interventions - Forty-three animals were premedicated with methadone (0.1-0.5 mg/kg) and acepromazine (0.01-0.05 mg/kg) intramuscularly. Twenty-three animals were premedicated with methadone alone (0.1-0.5 mg/kg) intramuscularly. Anesthesia was induced with propofol intravenously and maintained with isoflurane delivered in 100% oxygen. All animals received a balanced isotonic crystalloid solution intravenously at a rate of 10 mL/kg/h. Blood pressure, end-tidal CO2, oxygen saturation, respiratory rate, and heart rate were monitored throughout anesthesia. Animals requiring surgery immediately following myelography were excluded from the study.
Measurements and Main Results - The frequency of seizures was 14% (CI: 3.6-24.3%) and 13.0% (CI: 0.7-27%) in dogs that received methadone/acepromazine and methadone alone, respectively. There was no significant difference in the frequency of seizures between dogs receiving methadone/acepromazine or methadone alone (P = 1). Analysis of the association of site of injection of the contrast and the frequency of seizures in dogs receiving methadone/acepromazine showed no significant difference in the frequency of seizures following cervical injection (25%; CI: 0.5-24.5%) or lumbar injection (9.7%; CI: -0.7-20.1%).
Conclusions - The administration of acepromazine combined with methadone as a premedicant used with propofol and isoflurane anesthesia did not significantly increase the frequency of seizures following myelography compared to dogs who received methadone alone.
Details
- Title
- Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography
- Authors/Creators
- E.A. Drynan (Author/Creator)P. Gray (Author/Creator)A.L. Raisis (Author/Creator)
- Publication Details
- Journal of Veterinary Emergency and Critical Care, Vol.22(2), pp.262-266
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005540439307891
- Copyright
- © Veterinary Emergency and Critical Care Society 2012
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1642 Veterinary Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science