Journal article
Inclusion body myositis: Current pathogenetic concepts and diagnostic and therapeutic approaches
The Lancet Neurology, Vol.6(7), pp.620-631
2007
Abstract
Inclusion body myositis is the most common acquired muscle disease in older individuals, and its prevalence varies among countries and ethnic groups. The aetiology and pathogenesis of sporadic inclusion body myositis are still poorly understood; however genetic factors, ageing, and environmental triggers might all have a role. Unlike other inflammatory myopathies, sporadic inclusion body myositis causes slowly progressing muscular weakness and atrophy, it has a distinctive pattern of muscle involvement, and is unresponsive to conventional forms of immunotherapy. This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis...
Details
- Title
- Inclusion body myositis: Current pathogenetic concepts and diagnostic and therapeutic approaches
- Authors/Creators
- M. Needham (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- The Lancet Neurology, Vol.6(7), pp.620-631
- Publisher
- Elsevier
- Identifiers
- 991005540306707891
- Copyright
- © 2007 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior