Inclusion body myositis: Investigation of the mumps virus hypothesis by polymerase chain reaction

S.A. Fox; B.K. Ward; P.D. Robbins; F.L. Mastaglia; N.R. Swanson

doi:10.1002/(SICI)1097-4598(199601)19:1<23::AID-MUS4>3.0.CO;2-A

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Inclusion body myositis: Investigation of the mumps virus hypothesis by polymerase chain reaction

Journal article

Peer reviewed

Inclusion body myositis: Investigation of the mumps virus hypothesis by polymerase chain reaction

S.A. Fox, B.K. Ward, P.D. Robbins, F.L. Mastaglia and N.R. Swanson

Muscle & Nerve, Vol.19(1), pp.23-28

1996

DOI: https://doi.org/10.1002/(SICI)1097-4598(199601)19:1<23::AID-MUS4>3.0.CO;2-A

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Abstract

Inclusion body myositis (IBM) is a distinctive form of chronic inflammatory myopathy characterized pathologically by the finding of rimmed vacuoles and 15-18nm microtubular filamentous inclusions in muscle fiber nuclei and cytoplasm. The observation that these filaments resembled nucleocapsids of the paramyxovirus group and showed immunoreactivity with mumps virus (MV) antibodies has led to a long-standing postulate that IBM may be a "slow" mumps infection. We searched for the presence of MV RNA in 34 muscle biopsies (17 frozen and 17 paraffin-embedded) from 18 patients with IBM and 43 control biopsies (mainly from patients with other forms of inflammatory myopathy) using a polymerase chain reaction (PCR). The MV PCR was shown to be sensitive and specific for MV strains (including J-L) and the integrity of muscle RNA extracts was confirmed by PCR detection of constitutive Ableson tyrosine kinase mRNA. MV RNA was not found in any biopsy from the IBM group nor any of the control cases. Our results therefore do not support the mumps hypothesis for IBM.

Details

Title: Inclusion body myositis: Investigation of the mumps virus hypothesis by polymerase chain reaction
Authors/Creators: S.A. Fox (Author/Creator)
B.K. Ward (Author/Creator)
P.D. Robbins (Author/Creator)
F.L. Mastaglia (Author/Creator)
N.R. Swanson (Author/Creator)
Publication Details: Muscle & Nerve, Vol.19(1), pp.23-28
Publisher: John Wiley and Sons Inc.
Identifiers: 991005540765407891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1684 Dermatomyositis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior