Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

Gary Frost; Joana C Vasconcelos; Jennifer E Pugh; Aisha Anjum; Katerina Petropoulou; George Thom; Louise McCombie; Martina Tashkova; Sumayya Alshehhi; Daphne Babalis; Leah Holroyd; Christina Prechtl; Tom Preston; Mike J Lean; Waljit Dhillo; A Toby Prevost; and Douglas Morrison

doi:10.3310/GKWP5267

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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, …

Efficacy and mechanism evaluation, Vol.12(8), pp.1-72

2025

DOI: https://doi.org/10.3310/GKWP5267

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Abstract

Background: Overweight and obesity affect over 60% of the United Kingdom population and constitute a major risk factor for the development of comorbidities. Preventing weight gain in periods of life where there is an elevated risk of adipose tissue expansion could be beneficial in preventing associated diseases in later life. This study investigated the impact of inulin-propionate ester on the prevention of weight gain in young people who were at risk of gaining weight.

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Title: Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial
Authors/Creators: Gary Frost - Imperial College London
Joana C Vasconcelos - King's College London
Jennifer E Pugh - Imperial College London
Aisha Anjum - Imperial College London
Katerina Petropoulou - Imperial College London
George Thom - University of Glasgow
Louise McCombie - University of Glasgow
Martina Tashkova - Imperial College London
Sumayya Alshehhi - Imperial College London
Daphne Babalis - Imperial College London
Leah Holroyd - School of Advanced Study
Christina Prechtl - Imperial College London
Tom Preston - Scottish Universities Environmental Research Centre
Mike J Lean - University of Glasgow
Waljit Dhillo - Imperial College London
A Toby Prevost - King's College London
and Douglas Morrison - University of Glasgow
Publication Details: Efficacy and mechanism evaluation, Vol.12(8), pp.1-72
Publisher: NIHR Journals Library
Number of pages: 72
Identifiers: 991005884850107891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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