Journal article
Increased glycolysis in ageing cultured human diploid fibroblasts
Bioscience Reports, Vol.4(9), pp.751-756
09/1984
Abstract
With increasing population doubling in vitro, human diploid fibroblasts exhibited a highly significant increase in glucose uptake from the growth medium and a corresponding increase in lactate production. The switch to glycolysis occurred prior to the onset of changes in intracellular glucose and lactate concentrations or in the specific activity of the glycolytic regulatory enzyme, pyruvate kinase. It also preceded the morphological alterations held to be characteristic of cellular senescence.
Details
- Title
- Increased glycolysis in ageing cultured human diploid fibroblasts
- Authors/Creators
- A.H. Bittles (Author/Creator)N. Harper (Author/Creator)
- Publication Details
- Bioscience Reports, Vol.4(9), pp.751-756
- Publisher
- Portland Press
- Identifiers
- 991005540219407891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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