Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese

A. Asser; S. Kõks; A. Snellman; M. Haaparanta-Solin; E. Arponen; T. Grönroos; J. Nairismägi; J. Bergquist; U. Soomets; P. Piip; M. Eltermaa; M. Sauk; H. Lindmäe; J.O. Rinne; P. Taba

doi:10.1016/j.brainres.2016.09.034

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Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese

Journal article

Peer reviewed

Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese

A. Asser, S. Kõks, A. Snellman, M. Haaparanta-Solin, E. Arponen, T. Grönroos, J. Nairismägi, J. Bergquist, U. Soomets, P. Piip, …

Brain Research, Vol.1652, pp.97-102

2016

DOI: https://doi.org/10.1016/j.brainres.2016.09.034

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Abstract

Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage. C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [11C]dihydrotetrabenazine ([11C]DTBZ). After 27 weeks of treatment [11C]DTBZ autoradiography demonstrated a significant increase in the striatum-to-cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity. Increased [11C]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.

Details

Title: Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
Authors/Creators: A. Asser (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
A. Snellman (Author/Creator) - Turku PET Centre
M. Haaparanta-Solin (Author/Creator) - Turku PET Centre
E. Arponen (Author/Creator) - Turku PET Centre
T. Grönroos (Author/Creator) - Turku PET Centre
J. Nairismägi (Author/Creator) - Tallinn University of Technology
J. Bergquist (Author/Creator) - Uppsala University
U. Soomets (Author/Creator) - University of Tartu
P. Piip (Author/Creator) - University of Tartu
M. Eltermaa (Author/Creator) - University of Tartu
M. Sauk (Author/Creator) - University of Tartu
H. Lindmäe (Author/Creator) - University of Tartu
J.O. Rinne (Author/Creator) - Turku University Hospital
P. Taba (Author/Creator) - University of Tartu
Publication Details: Brain Research, Vol.1652, pp.97-102
Publisher: Elsevier BV
Identifiers: 991005544818007891
Copyright: © 2016 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.91 Contamination & Phytoremediation; 3.91.2269 Manganese Neurotoxicity
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior