Journal article
Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
Brain Research, Vol.1652, pp.97-102
2016
Abstract
Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage.
C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [11C]dihydrotetrabenazine ([11C]DTBZ).
After 27 weeks of treatment [11C]DTBZ autoradiography demonstrated a significant increase in the striatum-to-cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity.
Increased [11C]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.
Details
- Title
- Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
- Authors/Creators
- A. Asser (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuA. Snellman (Author/Creator) - Turku PET CentreM. Haaparanta-Solin (Author/Creator) - Turku PET CentreE. Arponen (Author/Creator) - Turku PET CentreT. Grönroos (Author/Creator) - Turku PET CentreJ. Nairismägi (Author/Creator) - Tallinn University of TechnologyJ. Bergquist (Author/Creator) - Uppsala UniversityU. Soomets (Author/Creator) - University of TartuP. Piip (Author/Creator) - University of TartuM. Eltermaa (Author/Creator) - University of TartuM. Sauk (Author/Creator) - University of TartuH. Lindmäe (Author/Creator) - University of TartuJ.O. Rinne (Author/Creator) - Turku University HospitalP. Taba (Author/Creator) - University of Tartu
- Publication Details
- Brain Research, Vol.1652, pp.97-102
- Publisher
- Elsevier BV
- Identifiers
- 991005544818007891
- Copyright
- © 2016 Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
21 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.91 Contamination & Phytoremediation
- 3.91.2269 Manganese Neurotoxicity
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior