Journal article
Increasing secondary resistance to fluoroquinolones amongst Helicobacter pylori in Western Australia
Tasman Madical Journal, Vol.2(1), pp.15-19
2020
Abstract
Background: The Australian Therapeutic Guidelines does not endorse culture and susceptibility testing prior to salvage therapy for Helicobacter pylorieradication. We wished to determine whether this remains appropriate.
Aim: To determine the sensitivity (as minimum inhibitory concentrations, MIC) of H pylorito a range of antibiotics used in salvage therapy over time.
Methods: From 2012 to 2017, gastric or duodenal biopsy samples were obtained from 154 patients receiving H pylorieradication therapy. MIC for amoxicillin, clarithromycin, tetracycline, metronidazole, rifampicin and levofloxacinwere measured using standard laboratory techniques.
Results: A significant increase from zero to 28% in secondary resistance to levofloxacin amongst H. pyloriin Western Australia was noted over the study period. No corresponding trend was seen with the other antibiotics.
Conclusions: These findings suggest that selective use of culture and susceptibility testing may be warranted prior to initiating salvage therapy with levofloxacin.
Details
- Title
- Increasing secondary resistance to fluoroquinolones amongst Helicobacter pylori in Western Australia
- Authors/Creators
- P. Pateria (Author/Creator)M. Chin (Author/Creator)R. Goodheart (Author/Creator)C. McCullough (Author/Creator)E. Raby (Author/Creator)J.O. Robinson (Author/Creator)P.R. Ingram (Author/Creator)
- Publication Details
- Tasman Madical Journal, Vol.2(1), pp.15-19
- Publisher
- Tasman Journals
- Identifiers
- 991005543803307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Publisher URL
- https://tasmanmedicaljournal.com/2020/03/increasing-secondary-resistance-to-fluoroquinolones-amongst-helicobacter-pylori-in-western-australia/
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