Journal article
Inefficacy of selegiline in treatment of canine pituitary-dependent hyper-adrenocorticism
Australian Veterinary Journal, Vol.82(5), pp.272-277
2004
Abstract
Objective: To evaluate selegiline, a monoamine oxidase-B inhibitor, for treating dogs with pituitary-dependent hyperadrenocorticism. Design: Prospective clinical trial using client-owned dogs with pituitary-dependent hyperadrenocorticism treated at The University Veterinary Centre, Sydney, from September 1999 to July 2001. Procedure: Eleven dogs with pituitary-dependent hyperadrenocorticism treated with selegiline were monitored at days 10, 30 and 90 by clinical examination, tetracosactrin stimulation testing, urinary corticoid:creatinine ratio measurement and client questionnaire. Endogenous adrenocorticotropic hormone measurements were also performed on most dogs on days 0 and 90. Results: No dog treated with selegiline had satisfactory control of disease. Conclusion: Selegiline administration was safe and free of side-effects at the doses used, but did not satisfactorily control disease in pituitary-dependent hyperadrenocorticism affected dogs.
Details
- Title
- Inefficacy of selegiline in treatment of canine pituitary-dependent hyper-adrenocorticism
- Authors/Creators
- J.A. Braddock (Author/Creator)D.B. Church (Author/Creator)I.D. Robertson (Author/Creator)A.D.J. Watson (Author/Creator)
- Publication Details
- Australian Veterinary Journal, Vol.82(5), pp.272-277
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005540566207891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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