Infant diet recommendations reduce IgE-mediated egg, peanut and cow’s milk allergies

Summer V.M. Walker; Nina D'Vaz; Rachelle Pretorius; Johnny Lo; Claus T. Christophersen; Susan L. Prescott; Debra J. Palmer

doi:10.1016/j.jaip.2025.06.012

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Infant diet recommendations reduce IgE-mediated egg, peanut and cow’s milk allergies

Journal article

Open access

Peer reviewed

Infant diet recommendations reduce IgE-mediated egg, peanut and cow’s milk allergies

Summer V.M. Walker, Nina D'Vaz, Rachelle Pretorius, Johnny Lo, Claus T. Christophersen, Susan L. Prescott and Debra J. Palmer

The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(11), pp.3077-3083.e1

2025

DOI: https://doi.org/10.1016/j.jaip.2025.06.012

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Abstract

Allergy and Immunology

Internal Medicine

maternal nutrition

Infant nutrition

feeding guidelines

allergy prevention

Allergy

Infant and child health

Food sciences not elsewhere classified

Nutrition and dietetics

Immunology

Background: Meta-analyses of randomized controlled trials have found that introducing eggs and peanuts earlier during infancy reduced egg and peanut allergy risk. Hence, infant feeding advice has dramatically changed from previous recommendations of avoidance to current recommendations of inclusion of common food allergens in infant diets. Objective: To compare the prevalence of IgE-mediated food allergies at 1-year of age between two cohorts, before and after infant feeding and allergy prevention guidelines changed. Methods: In cohort 1 (506 infants born 2006-2014), no infant feeding advice was provided to participants. In cohort 2 (566 infants born 2016-2022), when the infants were 6 months of age, all families were provided with updated infant feeding and allergy prevention guidelines. All infants had a first-degree relative with a history of allergic disease. At 1-year of age, infant food allergen sensitization and IgE-mediated food allergy were assessed. Results: Peanut, egg and cow’s milk were introduced earlier in cohort 2 compared to cohort 1 (all p<0.001). Combined prevalence of IgE-mediated peanut, egg and/or cow’s milk allergies was 4.1% in cohort 2 compared to 12.6% in cohort 1, adjusted odd ratio (aOR) 0.28, 95% CI 0.16-0.48, p<0.001). Specifically, peanut allergy 1.1% vs 5.8% (aOR 0.24, 95% CI 0.08-0.76, p=0.015), egg allergy 2.8% vs 11.7% (aOR 0.23, 95% CI 0.12-0.45, p<0.001), and cow’s milk allergy 0.5% vs 2.4% (aOR 0.14, 95% CI 0.04-0.55, p=0.005). Conclusion: Direct provision of updated food allergy prevention guidelines to families facilitated earlier introduction and reduced prevalence of IgE-mediated peanut, egg and cow’s milk allergies.

Details

Title: Infant diet recommendations reduce IgE-mediated egg, peanut and cow’s milk allergies
Authors/Creators: Summer V.M. Walker (Author)
Nina D'Vaz
Rachelle Pretorius
Johnny Lo
Claus T. Christophersen
Susan L. Prescott
Debra J. Palmer (Corresponding Author)
Publication Details: The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(11), pp.3077-3083.e1
Publisher: Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
Identifiers: 991005788581807891
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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