Journal article
Infections in neuromyelitis optica spectrum disorder
Journal of Clinical Neuroscience, Vol.47, pp.14-19
2017
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory astrocytopathy that has both genetic and environmental causes. A growing body of evidence suggests that the presence of several infectious agents correlates with the development of NMOSD. In this review, we summarize studies that either support or present evidence against the hypothesized association between infection and NMOSD. We will also present an overview of potential mechanisms underlying the pathogenesis of NMOSD. Finally, we provide some beneficial properties that infectious elements may have based on “hygiene hypothesis”. It is of great clinical significance to further investigate the complex mechanisms by which infections may affect autoimmune diseases to develop better strategies to prevent and treat them, although so far no causal link between infectious agents and NMOSD has been established.
Details
- Title
- Infections in neuromyelitis optica spectrum disorder
- Authors/Creators
- X. Zhong (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Zhou (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityT. Lu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityZ. Wang (Author/Creator) - Guangdong 999 Brain HospitalL. Fang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityL. Peng (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA.G. Kermode (Author/Creator) - Sir Charles Gairdner HospitalW. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
- Publication Details
- Journal of Clinical Neuroscience, Vol.47, pp.14-19
- Publisher
- Elsevier
- Identifiers
- 991005540248407891
- Copyright
- © 2017 Elsevier Ltd
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior