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Journal article
Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis
Frontiers in endocrinology (Lausanne), Vol.16, 1600565
2025
PMID: 41334449
Abstract
Background: Diabetes mellitus (DM) has emerged as a rapidly growing global health problem, imposing substantial socioeconomic burdens and multidimensional health consequences, including adverse effects on male fertility. Although accumulating evidence suggests associations between DM and male reproductive dysfunction, comprehensive mechanistic insights, particularly through inflammatory pathways, remain inadequately elucidated.
Method: We conducted a systematic literature search on Web of Science, Embase, and PubMed databases (1972–2022) to investigate DM-related male infertility through meta-analysis. Following PRISMA guidelines, eight of 168 studies on type 1 diabetes (T1D) and nine of 185 studies on type 2 diabetes (T2D) were included to screen the relationship between diabetes and male infertility. In addition, 10 of 840 inflammation-related studies (1961–2022) underwent rigorous selection for mechanistic exploration. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) across the combined studies.
Results: Meta-analysis demonstrated a significant impairment of male fertility in diabetic populations. Subgroup analyses revealed that T2D is more likely to cause male infertility compared to T1D. Despite low between-study heterogeneity, inflammation biomarkers (e.g., TNF-α) were implicated in diabetes-induced male infertility. Transcriptomic analyses further identified enriched inflammatory pathways and altered expression of fertility-related genes.
Conclusion: Current evidence indicates that diabetes adversely affects male fertility through inflammatory pathways.
Details
- Title
- Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis
- Authors/Creators
- Yanan Hao - Qingdao Agricultural UniversityZheng Yang - Murdoch UniversityYanni Feng - Qingdao Agricultural UniversityYong Zhao - Chinese Academy of Agricultural EngineeringYonglin Ren - Murdoch University
- Publication Details
- Frontiers in endocrinology (Lausanne), Vol.16, 1600565
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005849988107891
- Copyright
- © 2025 Hao et al.
- Murdoch Affiliation
- College of Environmental and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.176 Male Fertility
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Clinical Medicine