Journal article
Inflammatory myopathies: Clinical, diagnostic and therapeutic aspects
Muscle & Nerve, Vol.27(4), pp.407-425
2003
Abstract
The three major forms of immune-mediated inflammatory myopathy are dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). They each have distinctive clinical and histopathologic features that allow the clinician to reach a specific diagnosis in most cases. Magnetic resonance imaging is sometimes helpful, particularly if the diagnosis of IBM is suspected but has not been formally evaluated. Myositis-specific antibodies are not helpful diagnostically but may be of prognostic value; most antibodies have low sensitivity. Muscle biopsy is mandatory to confirm the diagnosis of an inflammatory myopathy and to allow unusual varieties such as eosinophilic, granulomatous, and parasitic myositis, and macrophagic myofasciitis, to be recognized. The treatment of the inflammatory myopathies remains largely empirical and relies upon the use of corticosteroids, immunosuppressive agents, and intravenous immunoglobulin, all of which have nonselective effects on the immune system. Further controlled clinical trials are required to evaluate the relative efficacy of the available therapeutic modalities particularly in combinations, and of newer immunosuppressive agents (mycophenolate mofetil and tacrolimus) and cytokine-based therapies for the treatment of resistant cases of DM, PM, and IBM. Improved understanding of the molecular mechanisms of muscle injury in the inflammatory myopathies should lead to the development of more specific forms of immunotherapy for these conditions.
Details
- Title
- Inflammatory myopathies: Clinical, diagnostic and therapeutic aspects
- Authors/Creators
- F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical CentreM.J. Garlepp (Author/Creator) - Curtin UniversityB.A. Phillips (Author/Creator) - The University of MelbourneP.J. Zilko (Author/Creator) - Sir Charles Gairdner Hospital
- Publication Details
- Muscle & Nerve, Vol.27(4), pp.407-425
- Publisher
- John Wiley and Sons Inc.
- Identifiers
- 991005545428007891
- Copyright
- © 2003 Wiley Periodicals, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior