Journal article
Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults
Behavioural Brain Research, Vol.362, pp.103-108
2019
Abstract
Higher cardiorespiratory fitness has been associated with better cognitive function in older adults; yet, this relationship demonstrates a degree of variability across the older adult population. Thus, it is hypothesised that variation in genetic factors may influence the relationship between fitness and cognitive health. One such genetic factor is the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, which has previously been shown to moderate the relationship between self-reported physical activity and memory performance. In this study we aim to investigate the interaction between BDNF Val66Met polymorphism and objectively-measured cardiorespiratory fitness on performance on tasks assessing verbal and visuospatial memory. Data from ninety-nine cognitively normal men and women aged 60–80 years were used. Fitness was assessed by peak oxygen consumption, and verbal and visuospatial memory were evaluated using well-validated measures. Participants were categorised into: lower-fit Met carriers, higher-fit Met carriers, lower-fit Val/Val, or higher-fit Val/Val. Higher-fit individuals performed better on a task assessing visuospatial memory, compared with lower-fit individuals. Furthermore, an interaction between BDNF Val66Met and fitness was observed in terms of visuospatial memory performance on a continuous paired associate learning task; whereby lower-fit Met carriers performed 1 standard deviation worse than higher-fit Met carriers. No differences were observed between the higher-fit and lower-fit Val/Val homozygotes. Future intervention studies should evaluate the effect of structured exercise on cognitive health between BDNF Val66Met carriers and Val/Val homozygotes.
Details
- Title
- Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults
- Authors/Creators
- B.M. Brown (Author/Creator) - Murdoch UniversityN. Castalanelli (Author/Creator)S.R. Rainey-Smith (Author/Creator)J. Doecke (Author/Creator) - Cooperative Research Centre for Mental HealthM. Weinborn (Author/Creator) - The University of Western AustraliaH.R. Sohrabi (Author/Creator) - Australian Alzheimer’s Research FoundationS.M. Laws (Author/Creator) - Murdoch UniversityR.N. Martins (Author/Creator) - Macquarie UniversityJ.J. Peiffer (Author/Creator) - Murdoch University
- Publication Details
- Behavioural Brain Research, Vol.362, pp.103-108
- Publisher
- Elsevier B.V.
- Identifiers
- 991005545308107891
- Copyright
- © 2019 Elsevier B.V.
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.767 Hippocampal Neurogenesis
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior