Journal article
Influence of HLA-C expression level on HIV control
Science, Vol.340(6128), pp.87-91
2013
Abstract
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn’s disease, suggesting a broader influence of HLA expression levels in human disease.
Details
- Title
- Influence of HLA-C expression level on HIV control
- Authors/Creators
- R. Apps (Author/Creator) - Science Applications International Corporation (United States)Y. Qi (Author/Creator) - Science Applications International Corporation (United States)J.M. Carlson (Author/Creator) - Microsoft (United States)H. Chen (Author/Creator) - University of California, San FranciscoX. Gao (Author/Creator) - Science Applications International Corporation (United States)R. Thomas (Author/Creator) - Science Applications International Corporation (United States)Y. Yuki (Author/Creator) - Science Applications International Corporation (United States)G.Q. Del Prete (Author/Creator) - Frederick National Laboratory for Cancer ResearchP. Goulder (Author/Creator)Z.L. Brumme (Author/Creator) - Simon Fraser UniversityC.J. Brumme (Author/Creator) - AIDS VancouverM. John (Author/Creator) - Murdoch UniversityS. Mallal (Author/Creator) - Murdoch UniversityG. Nelson (Author/Creator) - Frederick National Laboratory for Cancer ResearchR. Bosch (Author/Creator) - Cancer Research And BiostatisticsD. Heckerman (Author/Creator) - Microsoft (Canada)J.L. Stein (Author/Creator) - Duke UniversityK.A. Soderberg (Author/Creator) - Duke UniversityM.A. Moody (Author/Creator) - Duke UniversityT.N. Denny (Author/Creator) - Duke UniversityX. Zeng (Author/Creator) - Guang’anmen HospitalJ. Fang (Author/Creator) - Shanghai Jiao Tong UniversityA. Moffett (Author/Creator) - University of CambridgeJ.D. Lifson (Author/Creator) - Frederick National Laboratory for Cancer ResearchJ.J. Goedert (Author/Creator) - National Cancer InstituteS. Buchbinder (Author/Creator) - San Francisco Department of Public HealthG.D. Kirk (Author/Creator) - Bloomberg (United States)J. Fellay (Author/Creator) - École Polytechnique Fédérale de LausanneP. McLaren (Author/Creator)S.G. Deeks (Author/Creator) - University of California, San FranciscoF. Pereyra (Author/Creator) - Ragon Institute of MGH, MIT and HarvardB. Walker (Author/Creator) - Ragon Institute of MGH, MIT and HarvardN.L. Michael (Author/Creator) - United States Military HIV Research ProgramA. Weintrob (Author/Creator) - Uniformed Services University of the Health SciencesS. Wolinsky (Author/Creator) - Northwestern UniversityW. Liao (Author/Creator) - University of California, San FranciscoM. Carrington (Author/Creator) - Leidos (United States)
- Publication Details
- Science, Vol.340(6128), pp.87-91
- Publisher
- American Association for the Advancement of Science
- Identifiers
- 991005542772007891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology