Journal article
Influence of host resistance on viral adaptation: hepatitis C virus as a case study
Infection and Drug Resistance, Vol.8, pp.63-74
2015
Abstract
Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pressure via protein–protein interactions and sequence-specific mutations. Specifically, we will present the “state of play” on viral escape mutations to host T-cell responses in the context of the hepatitis C virus, and their influence on infection outcome.
Details
- Title
- Influence of host resistance on viral adaptation: hepatitis C virus as a case study
- Authors/Creators
- S. Gaudieri (Author/Creator) - The University of Western AustraliaA. Plauzolles (Author/Creator) - The University of Western AustraliaM. Lucas (Author/Creator) - Harry Perkins Institute of Medical Research
- Publication Details
- Infection and Drug Resistance, Vol.8, pp.63-74
- Publisher
- Dove Press
- Identifiers
- 991005540225707891
- Copyright
- © 2015 Plauzolles et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Infectious Diseases
- Pharmacology & Pharmacy
- ESI research areas
- Immunology