Journal article
Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection
Tissue Antigens, Vol.69(SUPPL. 1), pp.237-240
01/04/2007
Abstract
An estimated 2%-3% of the world's population is chronically infected with hepatitis C virus (HCV) and this is a major cause of liver disease worldwide. Following acute infection, outcome is variable with acute HCV successfully resolved in some individuals (20%-30%), but in the majority of cases the virus is able to persist. Co-infection with human immunodeficiency virus has been associated with a negative impact on the course of HCV infection. The host's immune response is an important correlate of HCV infection outcome and disease progression. Natural killer (NK) cells provide a major component of the antiviral immune response by recognising and killing virally infected cells. NK cells modulate their activity through a combination of inhibitory and activatory receptors such as the killer immunoglobulin-like receptors (KIRs) that bind to human leukocyte antigen (HLA) Class I molecules. In this workshop component, we addressed the influence of KIR genotypes and their HLA ligands on resolving HCV infection and we discuss the implications of the results of the study of Lopez-Vazquez et al. on KIR and HCV disease progression.
Details
- Title
- Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection
- Authors/Creators
- A. Rauch (Author/Creator)R. Laird (Author/Creator)E. McKinnon (Author/Creator)A. Telenti (Author/Creator)H. Furrer (Author/Creator)R. Weber (Author/Creator)D. Smillie (Author/Creator)S. Gaudieri (Author/Creator)
- Publication Details
- Tissue Antigens, Vol.69(SUPPL. 1), pp.237-240
- Publisher
- Blackwell Publishing
- Identifiers
- 991005541711207891
- Copyright
- © 2007 Blackwell Munksgaard.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1021 Natural Killer Cells
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics