Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability

A. Ouadi; A. Loussouarn; L. Morandeau; P. Remaud; A. Faivre-Chauvet; J. Webb; J-F Gestin

doi:10.1016/j.ejmech.2004.02.009

Back

Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability

Journal article

Peer reviewed

Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability

A. Ouadi, A. Loussouarn, L. Morandeau, P. Remaud, A. Faivre-Chauvet, J. Webb and J-F Gestin

European Journal of Medicinal Chemistry, Vol.39(5), pp.467-472

2004

DOI: https://doi.org/10.1016/j.ejmech.2004.02.009

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

A simple procedure was developed to compare chelating agents for 153Sm complexes as a preliminary step to synthesise bifunctional analogues. Several variables affecting the efficiency of complex stability were investigated, such as the pre-organisation concept, cavity size, and the nature of coordination sites. Four semi-rigid agents incorporating carboxylic and/or phosphonic groupings fixed at trans-1,2-diaminocyclohexane were evaluated for their 153Sm chelation properties, and competition studies were performed. Data on the stability of the best chelating agent compound 3: trans-cyclohexane-1,2-bis(aminomethylphosphonic)-N,N′-bis(ethyl-2- iminodiacetic acid) in human serum are presented.

Details

Title: Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability
Authors/Creators: A. Ouadi (Author/Creator) - Inserm
A. Loussouarn (Author/Creator) - CHELATEC, institut de biologie, 9, quai Moncousu, 44093 Nantes cedex, France
L. Morandeau (Author/Creator) - Murdoch University
P. Remaud (Author/Creator) - Inserm
A. Faivre-Chauvet (Author/Creator) - Inserm
J. Webb (Author/Creator) - Murdoch University
J-F Gestin (Author/Creator) - Inserm
Publication Details: European Journal of Medicinal Chemistry, Vol.39(5), pp.467-472
Publisher: Elsevier Masson SAS
Identifiers: 991005543388507891
Copyright: © 2004 Elsevier SAS.
Murdoch Affiliation: School of Chemical and Mathematical Science
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

54 Record Views

14 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.204 Molecular & Cell Biology - Immunotherapy; 1.204.1095 Radioimmunotherapy
Web Of Science research areas: Chemistry, Medicinal
ESI research areas: Chemistry