Journal article
Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability
European Journal of Medicinal Chemistry, Vol.39(5), pp.467-472
2004
Abstract
A simple procedure was developed to compare chelating agents for 153Sm complexes as a preliminary step to synthesise bifunctional analogues. Several variables affecting the efficiency of complex stability were investigated, such as the pre-organisation concept, cavity size, and the nature of coordination sites. Four semi-rigid agents incorporating carboxylic and/or phosphonic groupings fixed at trans-1,2-diaminocyclohexane were evaluated for their 153Sm chelation properties, and competition studies were performed. Data on the stability of the best chelating agent compound 3: trans-cyclohexane-1,2-bis(aminomethylphosphonic)-N,N′-bis(ethyl-2- iminodiacetic acid) in human serum are presented.
Details
- Title
- Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability
- Authors/Creators
- A. Ouadi (Author/Creator) - InsermA. Loussouarn (Author/Creator) - CHELATEC, institut de biologie, 9, quai Moncousu, 44093 Nantes cedex, FranceL. Morandeau (Author/Creator) - Murdoch UniversityP. Remaud (Author/Creator) - InsermA. Faivre-Chauvet (Author/Creator) - InsermJ. Webb (Author/Creator) - Murdoch UniversityJ-F Gestin (Author/Creator) - Inserm
- Publication Details
- European Journal of Medicinal Chemistry, Vol.39(5), pp.467-472
- Publisher
- Elsevier Masson SAS
- Identifiers
- 991005543388507891
- Copyright
- © 2004 Elsevier SAS.
- Murdoch Affiliation
- School of Chemical and Mathematical Science
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.204 Molecular & Cell Biology - Immunotherapy
- 1.204.1095 Radioimmunotherapy
- Web Of Science research areas
- Chemistry, Medicinal
- ESI research areas
- Chemistry