Journal article
Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze
Neuroreport, Vol.6(10), pp.1413-1416
1995
Abstract
The action of inhibition of nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester (L-NAME) (1-20 mg kg-1) on the exploratory behaviour of rats in the elevated plus-maze was studied. L-NAME induced an anxiolytic-like effect in the plus-maze test, showing a reverse U-shape action behaviour, with a maximal effect at 10 mg kg-1. This effect was not related to a non-specific increase in motor activity, since in the open field test L-NAME did not affect locomotor activity of rats. Pretreatment of rats with L-NAME (1-10 mg kg-1) also tended to attenuate the anti-exploratory action of CCK agonist caerulein (5 micrograms kg-1), but this action was not significant. In conclusion, it appears that NO may be involved in the process that can lead to anxiety in the rat.
Details
- Title
- Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze
- Authors/Creators
- V. Volke (Author/Creator) - University of TartuS. Kõks (Author/Creator)E. Vasar (Author/Creator)M. Bourin (Author/Creator)J. Bradwejn (Author/Creator)P.T. Männistö (Author/Creator)
- Publication Details
- Neuroreport, Vol.6(10), pp.1413-1416
- Publisher
- Lippincott Williams & Wilkins
- Identifiers
- 991005541546407891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.127 Molecular & Cell Biology - Pharmacology
- 1.127.87 Nitric Oxide Roles
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior