Journal article
Innervation and nerve-immune cell contacts in mouse Peyer's patches
Histology and Histopathology, Vol.35(4), pp.371-383
2020
Abstract
Neural regulation of the function of the gastrointestinal tract (GIT) relies on a delicate balance of the two divisions of its nervous system, namely, the intrinsic and extrinsic divisions. The intrinsic innervation is provided by the enteric nervous system (ENS), whereas the extrinsic innervation includes sympathetic/parasympathetic nerve fibers and extrinsic sensory nerve fibers. In the present study, we used immunofluorescent staining of neurofilament-heavy (NF-H) to reveal the distribution of nerve fibers and their associations with immune cells inside mouse Peyer's patches (PP), an essential part of gut-associated lymphoid tissue (GALT). Our results demonstrate (1) the presence of an extensive meshwork of NF-H-immunoreactive presumptive nerve fibers in all PP compartments including the lymphoid nodules, interfollicular region, follicle-associated epithelium, and subepithelial dome; (2) close associations/contacts of nerve fibers with blood vessels including high endothelial venules, indicating neural control of blood flow and immune cell dynamics inside the PP; (3) close contacts between nerve fibers/endings and B/T cells and various subsets of dendritic cells ( e.g., B220-, B220+, CD4-, CD4+, CD8-, and CD8+). Our novel findings concerning PP innervation and nerve-immune-cell contacts in situ should facilitate our understanding of bi-directional communications between the PNS and GALT. Since the innervation of the gut, including PP, might be important in the pathogenesis and progression of some neurological, infectious, and autoimmune diseases, e.g., prion diseases and inflammatory bowel disease, better knowledge of PNS-immune system interactions in the GALT (including PP) should benefit the development of potential treatments for these diseases via neuroimmune manipulations.
Details
- Title
- Innervation and nerve-immune cell contacts in mouse Peyer's patches
- Authors/Creators
- H.A.M. Al-Shalan (Author/Creator)D. Hu (Author/Creator)P.K. Nicholls (Author/Creator)W.K. Greene (Author/Creator)B. Ma (Author/Creator)
- Publication Details
- Histology and Histopathology, Vol.35(4), pp.371-383
- Publisher
- Histology and Histopathology
- Number of pages
- 13
- Identifiers
- 991005543018107891
- Copyright
- © 2020, Histology and Histopathology.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
- Publisher URL
- https://www.hh.um.es/Abstracts/Vol_/_/__18158.htm
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.1341 Enteric Nervous System
- Web Of Science research areas
- Cell Biology
- Pathology
- ESI research areas
- Biology & Biochemistry