Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents

R.A. Boulos; N.Y.T. Man; N.A. Lengkeek; K.A. Hammer; N.F. Foster; N.A. Stemberger; B.W. Skelton; P.Y. Wong; B. Martinac; T.V. Riley; A.J. McKinley; S.G. Stewart

doi:10.1002/chem.201303119

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Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents

Journal article

Peer reviewed

Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents

R.A. Boulos, N.Y.T. Man, N.A. Lengkeek, K.A. Hammer, N.F. Foster, N.A. Stemberger, B.W. Skelton, P.Y. Wong, B. Martinac, T.V. Riley, …

Chemistry - A European Journal, Vol.19(52), pp.17980-17988

2013

DOI: https://doi.org/10.1002/chem.201303119

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Abstract

Herein we describe the preparation and structure-activity relationship studies on range of stilbene based compounds and their antibacterial activity. Two related compounds, each bearing carboxylic acid moieties, exhibit good activity against several bacterial strains, including methicillin-resistant Staphylococcus aureus MRSA (ATCC 33592 and NCTC 10442). Compound 10 was most active against Moraxella catarrhalis with minimum inhibitory concentrations (MICs) of 0.12-0.25 μg mL-1 and against Staphylococcus spp. with MICs ranging from 2-4 μg mL-1. The derivative 17 showed increased activity with MICs of 0.06-0.25 μg mL-1 against M. catarrhalis and 0.12-1 against Staphylococcus spp. This level of activity is similar to that reported for S. aureus for antibiotics, such as vancomycin, with MICs of ≤2.0 μg mL-1 and clindamycin with MICs of ≤0.5 μg mL -1. As an indicator of toxicity, 17 was tested for its ability to lyse sheep erythrocytes, and showed low haemolytic activity. Such results highlight the value of tris(stilbene) compounds as antibacterial agents providing suitable properties for further development. Routes to new antibiotics: The preparation of and structure-activity relationship studies on a range of stilbene based compounds revealed two related compounds, each bearing carboxylic acid moieties, exhibiting pronounced activity against several bacterial strains including methicillin-resistant Staphylococcus aureus, MRSA (see scheme, dba = dibenzylidene acetone).

Details

Title: Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents
Authors/Creators: R.A. Boulos (Author/Creator)
N.Y.T. Man (Author/Creator)
N.A. Lengkeek (Author/Creator)
K.A. Hammer (Author/Creator)
N.F. Foster (Author/Creator)
N.A. Stemberger (Author/Creator)
B.W. Skelton (Author/Creator)
P.Y. Wong (Author/Creator)
B. Martinac (Author/Creator)
T.V. Riley (Author/Creator)
A.J. McKinley (Author/Creator)
S.G. Stewart (Author/Creator)
Publication Details: Chemistry - A European Journal, Vol.19(52), pp.17980-17988
Publisher: Wiley-VCH Verlag
Identifiers: 991005541809907891
Copyright: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.264 Longevity; 1.264.1102 Resveratrol & Sirtuins
Web Of Science research areas: Chemistry, Multidisciplinary
ESI research areas: Chemistry