Journal article
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
Scientific Reports, Vol.7(1), Art. 9766
2017
Abstract
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer’s disease (AD) pathological features. However, the association of T2D with pathological and clinical phenotypes in humans is unclear. Here we investigate the relationship of indices of IR (HOMA-IR) and pancreatic β-cell function (HOMA-B) with cognitive performance across several domains (Verbal/Visual Episodic Memory, Executive Function, Language and a measure of Global cognition) and AD biomarkers (CSF Aβ42, T-tau/P-tau, hippocampal volume and neocortical Aβ-amyloid burden). We reveal that HOMA-IR (p < 0.001) incrementally increases across diagnostic groups, becoming significantly elevated in the AD group compared with cognitively normal (CN) adults. In CN adults, higher HOMA-IR was associated with poorer performance on measures of verbal episodic memory (p = 0.010), executive function (p = 0.046) and global cognition (p = 0.007), as well as with higher CSF T-tau (p = 0.008) and P-tau (p = 0.014) levels. No association was observed with CSF Aβ or imaging modalities. Together our data suggest that IR may contribute to reduced cognitive performance and the accumulation of CSF tau biomarkers in cognitively normal adults.
Details
- Title
- Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
- Authors/Creators
- S.M. Laws (Author/Creator) - Edith Cowan UniversityS. Gaskin (Author/Creator) - Curtin UniversityA. Woodfield (Author/Creator) - Curtin UniversityV. Srikanth (Author/Creator) - Monash UniversityD. Bruce (Author/Creator) - The University of Western AustraliaP.E. Fraser (Author/Creator) - University of TorontoT. Porter (Author/Creator)P. Newsholme (Author/Creator) - Curtin UniversityN. Wijesekara (Author/Creator) - University of TorontoS. Burnham (Author/Creator) - Edith Cowan UniversityV. Doré (Author/Creator) - CSIRO Health and BiosecurityQ-X Li (Author/Creator) - Florey Institute of Neuroscience and Mental HealthP. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS. Rainey-Smith (Author/Creator) - Edith Cowan UniversityC.C. Rowe (Author/Creator) - Austin HealthO. Salvado (Author/Creator) - CSIRO Health and BiosecurityV.L. Villemagne (Author/Creator) - Austin HealthR.N. Martins (Author/Creator) - Edith Cowan UniversityG. Verdile (Author/Creator) - Edith Cowan University
- Publication Details
- Scientific Reports, Vol.7(1), Art. 9766
- Publisher
- Springer Nature
- Identifiers
- 991005542324107891
- Copyright
- © 2017 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior