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Journal article
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Nature communications, Vol.14(1), Art. 1530
2023
PMID: 36934086
Abstract
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.
Details
- Title
- Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
- Authors/Creators
- Andre Mu - Peter Doherty InstituteWilliam P Klare - The University of SydneySarah L Baines - The University of MelbourneC N Ignatius Pang - The University of SydneyRomain Guérillot - The University of MelbourneNichaela Harbison-Price - The University of QueenslandNadia Keller - The University of QueenslandJonathan Wilksch - The University of MelbourneNguyen Thi Khanh Nhu - The University of QueenslandMinh-Duy Phan - The University of QueenslandBernhard Keller - The University of QueenslandBrunda Nijagal - The University of MelbourneDedreia Tull - The University of MelbourneSaravanan Dayalan - The University of MelbourneHwa Huat Charlie Chua - The University of MelbourneDominik Skoneczny - The University of MelbourneJason Koval - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaAbderrahman Hachani - The University of MelbourneAnup D Shah - Monash UniversityNitika Neha - The University of MelbourneSnehal Jadhav - The University of MelbourneSally R Partridge - The University of SydneyAmanda J Cork - The University of QueenslandKate Peters - The University of QueenslandOlivia Bertolla - The University of QueenslandStephan Brouwer - The University of QueenslandSteven J Hancock - The University of QueenslandLaura Álvarez-Fraga - The University of QueenslandDavid M P De Oliveira - The University of QueenslandBrian Forde - The University of QueenslandAshleigh Dale - The University of SydneyWarasinee Mujchariyakul - The University of MelbourneCalum J Walsh - The University of MelbourneIan Monk - The University of MelbourneAnna Fitzgerald - Bioplatforms AustraliaMabel Lum - Bioplatforms AustraliaCarolina Correa-Ospina - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaPiklu Roy Chowdhury - Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, AustraliaRobert G Parton - The University of QueenslandJames De Voss - The University of QueenslandJames Beckett - The University of QueenslandFrancois Monty - AGRF LtdJessica McKinnon - Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, AustraliaXiaomin Song - Macquarie UniversityJohn R Stephen - AGRF LtdMarie Everest - AGRF LtdMatt I Bellgard - Center for Comparative Genomics, Murdoch University, Perth, WA, AustraliaMatthew Tinning - AGRF LtdMichael Leeming - The University of MelbourneDianna Hocking - The University of MelbourneLeila Jebeli - The University of MelbourneNancy Wang - The University of MelbourneNouri Ben Zakour - The University of SydneySerhat A Yasar - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaStefano Vecchiarelli - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaTonia Russell - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaThiri Zaw - Macquarie UniversityTyrone Chen - Monash UniversityDon Teng - The University of MelbourneZena Kassir - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaTrevor Lithgow - Monash UniversityAdam Jenney - Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, AustraliaJason N Cole - Skaggs School of Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093, USAVictor Nizet - Skaggs School of Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093, USATania C Sorrell - Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, AustraliaAnton Y Peleg - Monash UniversityDavid L Paterson - The University of QueenslandScott A Beatson - The University of QueenslandJemma Wu - Macquarie UniversityMark P Molloy - Macquarie UniversityAnna E Syme - The University of MelbourneRobert J A Goode - Commonwealth Scientific and Industrial Research OrganisationAdam A Hunter - Murdoch UniversityGrahame Bowland - Center for Comparative Genomics, Murdoch University, Perth, WA, AustraliaNicholas P West - The University of QueenslandMarc R Wilkins - Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaSteven P Djordjevic - Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, AustraliaMark R Davies - The University of MelbourneTorsten Seemann - The University of MelbourneBenjamin P Howden - The University of MelbourneDana Pascovici - Macquarie UniversitySonika Tyagi - Monash UniversityRalf B Schittenhelm - Monash UniversityDavid P De Souza - The University of MelbourneMalcolm J McConville - The University of MelbourneJonathan R Iredell - Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, AustraliaStuart J Cordwell - The University of SydneyRichard A Strugnell - The University of MelbourneTimothy P Stinear - The University of MelbourneMark A Schembri - The University of QueenslandMark J Walker - The University of Queensland
- Publication Details
- Nature communications, Vol.14(1), Art. 1530
- Publisher
- Springer Nature
- Identifiers
- 991005568769207891
- Copyright
- © 2023 The Author(s)
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1051 Streptococcal Infections
- Web Of Science research areas
- Microbiology
- ESI research areas
- Biology & Biochemistry