Intense resistance exercise increases peripheral brain-derived neurotrophic factor

K.J. Marston; M.J. Newton; B.M. Brown; S.R. Rainey-Smith; S.M. Bird; R.N. Martins; J.J. Peiffer

doi:10.1016/j.jsams.2017.03.015

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Intense resistance exercise increases peripheral brain-derived neurotrophic factor

Journal article

Open access

Peer reviewed

Intense resistance exercise increases peripheral brain-derived neurotrophic factor

K.J. Marston, M.J. Newton, B.M. Brown, S.R. Rainey-Smith, S.M. Bird, R.N. Martins and J.J. Peiffer

Journal of Science and Medicine in Sport, Vol.20(10), pp.899-903

2017

DOI: https://doi.org/10.1016/j.jsams.2017.03.015

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Abstract

Objectives: Brain-derived neurotrophic factor (BDNF) has been shown to increase in an intensity dependent manner in response to aerobic exercise. However, previous research investigating the use of resistance exercise to increase BDNF levels has been less conclusive, likely due to the low intensity nature of traditional resistance exercise programs. This study examined the influence of acute resistance exercise to-fatigue on serum BDNF levels and blood lactate. Design: Acute crossover study. Methods: Eleven untrained to intermediately trained males (age: 25.0. ±. 1.3 year) and five untrained females (age: 23.2. ±. 1.1 year) were recruited to undertake two bouts of resistance exercise. Strength (five sets of five repetitions, 180. s recovery) and hypertrophy (three sets of ten repetitions, 60. s recovery) based resistance exercise was implemented to-fatigue to examine the effect on serum BDNF and blood lactate levels immediately post-, and 30. min post-exercise. Results: An interaction (p. <. 0.01; ES = 0.52) was observed between conditions immediately post-exercise, with hypertrophy resulting in significantly greater BDNF levels when compared with strength exercise. Changes in lactate and BDNF from baseline to post- exercise were positively correlated following hypertrophy exercise (r = 0.70; p. <. 0.01), but not correlated following strength exercise (r = 0.18; p = 0.56). Conclusions: The use of a to-fatigue hypertrophy based resistance exercise protocol provides the necessary stimulus to increase peripheral serum BDNF. Mechanistically, the presence of lactate does not appear to drive the BDNF response during resistance exercise.

Details

Title: Intense resistance exercise increases peripheral brain-derived neurotrophic factor
Authors/Creators: K.J. Marston (Author/Creator) - Murdoch University
M.J. Newton (Author/Creator) - Murdoch University
B.M. Brown (Author/Creator) - Hollywood Private Hospital
S.R. Rainey-Smith (Author/Creator)
S.M. Bird (Author/Creator) - The University of Western Australia
R.N. Martins (Author/Creator) - The University of Western Australia
J.J. Peiffer (Author/Creator) - Murdoch University
Publication Details: Journal of Science and Medicine in Sport, Vol.20(10), pp.899-903
Publisher: Elsevier Ltd
Identifiers: 991005544913207891
Copyright: © 2017 Sports Medicine Australia
Murdoch Affiliation: School of Psychology and Exercise Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.767 Hippocampal Neurogenesis
Web Of Science research areas: Sport Sciences
ESI research areas: Clinical Medicine