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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Interferon-alpha, immune activation and immune dysfunction in treated HIV infection
Clinical & Translational Immunology, Vol.3(2), e10
2014
Abstract
Type I interferons (IFNs) exert anti-viral effects through the induction of numerous IFN-stimulated genes and an immunomodulatory effect on innate and adaptive immune responses. This is beneficial in controlling virus infections but prolonged IFN-α activity in persistent virus infections, such as HIV infection, may contribute to immune activation and have a detrimental effect on the function of monocytes and T and B lymphocytes. Activation of monocytes, associated with increased IFN-α activity, contributes to atherosclerotic vascular disease, brain disease and other ‘age-related diseases’ in HIV patients treated with long-term antiretroviral therapy (ART). In HIV patients receiving ART, the anti-viral effects of IFN-α therapy have the potential to contribute to eradication of HIV infection while IFN-α inhibitor therapy is under investigation for the treatment of immune activation. The management of HIV patients receiving ART will be improved by understanding more about the opposing effects of IFN-α on HIV infection and disease and by developing methods to assess IFN-α activity in clinical practice.
Details
- Title
- Interferon-alpha, immune activation and immune dysfunction in treated HIV infection
- Authors/Creators
- L. Cha (Author/Creator) - The University of Western AustraliaC.M. Berry (Author/Creator) - Murdoch UniversityD. Nolan (Author/Creator) - Royal Perth HospitalA. Castley (Author/Creator) - Murdoch UniversityS. Fernandez (Author/Creator) - The University of Western AustraliaM.A. French (Author/Creator) - The University of Western Australia
- Publication Details
- Clinical & Translational Immunology, Vol.3(2), e10
- Identifiers
- 991005540067107891
- Copyright
- © 2014 Australasian Society for Immunology Inc.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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