Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway

D.J.J. Carr; K. Al-khatib; C.M. James; R. Silverman

doi:10.1016/S0165-5728(03)00216-9

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Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway

Journal article

Peer reviewed

Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway

D.J.J. Carr, K. Al-khatib, C.M. James and R. Silverman

Journal of Neuroimmunology, Vol.141(1-2), pp.40-46

2003

DOI: https://doi.org/10.1016/S0165-5728(03)00216-9

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Abstract

The induction of an antiviral state by type I interferons (IFN) was evaluated in primary trigeminal ganglion cell cultures using herpes simplex virus type 1 (HSV-1). Cells treated with mouse IFN-β consistently showed the greatest resistance to HSV-1 infection in comparison to cells treated with IFN-α1, IFN-α4, IFN-α5, IFN-α6, or IFN-α9. The antiviral efficacy was dose-dependent and correlated with the induction of the IFN-inducible, antiviral genes, 2′–5′ oligoadenylate synthetase (OAS) and double-stranded RNA-dependent protein kinase. In trigeminal ganglion cells deficient in the downstream effector molecule of the OAS pathway, RNase L, the antiviral state induced by IFN-β was lost.

Details

Title: Interferon-β suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway
Authors/Creators: D.J.J. Carr (Author/Creator) - University of Oklahoma Health Sciences Center
K. Al-khatib (Author/Creator) - University of Oklahoma Health Sciences Center
C.M. James (Author/Creator) - Murdoch University
R. Silverman (Author/Creator) - Cleveland Clinic
Publication Details: Journal of Neuroimmunology, Vol.141(1-2), pp.40-46
Publisher: Elsevier
Identifiers: 991005542897307891
Copyright: 2003 Elsevier B.V
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.161 Virology - Identification & Sequencing; 1.161.315 Herpesvirus Dynamics
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior