Journal article
Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes
Journal of Psychiatric Research, Vol.44(5), pp.275-277
2010
Abstract
Genetic regulation of immune system and inflammatory response may be related to the pathogenesis and manifestations of mood and anxiety disorders. In the present study we examined a range of single-nucleotide polymorphisms (SNP) in chromosomal region 1q32, the locus of interleukin 10 (IL10) gene, in patients with major depressive disorder (n = 312) and panic disorder (n = 210), and matched healthy controls (n = 356). We found no significant associations of the SNPs in IL10 family genes with either diagnostic group. Haplotype analysis revealed seven haplotype blocks, but their frequencies did not differ between patients and controls. Significant associations were detected for SNP rs1539243 in IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) gene showing different allelic and genotypic distributions in the total as well as in separate diagnostic groups as compared to controls. IKBKE emerged as a candidate for further studies of genetic factors associated with panic disorder and major depressive disorder.
Details
- Title
- Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes
- Authors/Creators
- K. Koido (Author/Creator) - University of TartuT. Eller (Author/Creator) - University of TartuK. Kingo (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuT. Traks (Author/Creator) - University of TartuJ. Shlik (Author/Creator) - University of OttawaV. Vasar (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of TartuE. Maron (Author/Creator) - University of Tartu
- Publication Details
- Journal of Psychiatric Research, Vol.44(5), pp.275-277
- Publisher
- Elsevier
- Identifiers
- 991005544803807891
- Copyright
- © 2009 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.21 Psychiatry
- 1.21.1828 Neuroinflammation
- Web Of Science research areas
- Psychiatry
- ESI research areas
- Psychiatry/Psychology