Journal article
Intragenic variation of synonymous substitution rates is caused by nonrandom mutations at methylated CpG
Journal of Molecular Evolution, Vol.53(4-5), pp.456-464
2001
Abstract
It has been observed that synonymous substitution rates vary among genes in various organisms, although the cause of the variation is unresolved. At the intragenic level, however, the variation of synonymous substitutions is somewhat controversial. By developing a rigorous statistical test and applying the test to 418 homologous gene pairs between mouse and rat, we found that more than 90% of gene pairs showed a statistical significance in intragenic variation of synonymous substitution rates. Moreover, by examining all conceivable possibilities for the cause of the variation, we successfully found that intragenic variation of synonymous substitutions in mammalian genes is caused mainly by a nonrandom mutation due to the methylation of CpG dinucleotides rather than by functional constraints.
Details
- Title
- Intragenic variation of synonymous substitution rates is caused by nonrandom mutations at methylated CpG
- Authors/Creators
- K. Tsunoyama (Author/Creator)M.I. Bellgard (Author/Creator)T. Gojobori (Author/Creator)
- Publication Details
- Journal of Molecular Evolution, Vol.53(4-5), pp.456-464
- Publisher
- Springer-Verlag
- Identifiers
- 991005544409107891
- Murdoch Affiliation
- School of Information Technology
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
45 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.1935 Codon Usage
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Evolutionary Biology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics