Journal article
Intramuscular alfaxalone with or without buprenorphine or hydromorphone provides sedation with minimal adverse effects in healthy rabbits (Oryctolagus cuniculus) in a randomized blinded controlled trial
Journal of the American Veterinary Medical Association, Vol.261(2), pp.223-228
2023
PMID: 35388473
Abstract
OBJECTIVE To evaluate the effects of alfaxalone administered IM with or without buprenorphine or hydromorphone in healthy rabbits (Oryctolagus cuniculus).
ANIMALS 24 male rabbits undergoing elective orchiectomy between August 21, 2021, and November 6, 2021.
PROCEDURES In this controlled clinical trial, rabbits were randomly assigned to receive alfaxalone (4 mg/kg, IM) alone (group A; n = 8) or with buprenorphine (0.03 mg/kg, IM; group BA; 8) or hydromorphone (0.1 mg/kg, IM; group HA; 8). Vital signs and sedation scores were recorded immediately prior to (T0) and 10 minutes after (T1) treatment. Ease of IV catheter placement and pain scores were also evaluated. All rabbits received ketamine (2.5 mg/kg, IV), midazolam (0.13 mg/kg, IV), and meloxicam (0.5 mg/kg, SC) before orchiectomy but after IM treatments. Results were com-pared across groups with ANOVA or Fisher exact tests and across time with paired t tests.
RESULTS Sedation score, median time to recumbency, and ease of catheter placement did not differ among groups. Supra- glottic airway device placement was possible for 1 rabbit in group A, 1 in group BA, and 2 in group HA. Mean respi-ratory rate at T1 versus T0 was significantly decreased for groups BA (63.8 vs 128.6 breaths/min) and HA (66.7 vs 123.2 breaths/min). Mean postoperative pain scores were significantly lower for rabbits in group HA (0.58), com- pared with those in groups A (2.25) and BA (2.06).
CLINICAL RELEVANCE All 3 treatments provided reliable sedation; however, alfaxalone (4 mg/kg, IM) combined with hydromorphone (0.1 mg/kg, IM) may be a better choice for painful procedures.
Details
- Title
- Intramuscular alfaxalone with or without buprenorphine or hydromorphone provides sedation with minimal adverse effects in healthy rabbits (Oryctolagus cuniculus) in a randomized blinded controlled trial
- Authors/Creators
- Renata S. Costa - Midwestern State UniversityMiranda Ciotti-McClallen - Midwestern UniversityRachel Tilley - Midwestern UniversityStefanie Perry - Midwestern UniversityLynn Maki - Midwestern UniversityDarius Starks - Midwestern UniversityAmy B. Stein - Midwestern University
- Publication Details
- Journal of the American Veterinary Medical Association, Vol.261(2), pp.223-228
- Publisher
- Amer Veterinary Medical Assoc
- Number of pages
- 6
- Identifiers
- 991005593762507891
- Copyright
- © 2023 American Veterinary Medical Association
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
3 File views/ downloads
110 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1642 Veterinary Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science