Journal article
Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep
Laboratory Animals, Vol.47(1), pp.66-70
2013
Abstract
The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 mu L/h (3 mu g/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 mu g/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.
Details
- Title
- Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep
- Authors/Creators
- F.R. Murdoch (Author/Creator) - Murdoch UniversityG.L. Maker (Author/Creator) - Murdoch UniversityI. Nitsos (Author/Creator) - Monash Institute of Medical ResearchG.R. Polglase (Author/Creator) - Monash Institute of Medical ResearchG.C. Musk (Author/Creator) - Murdoch University
- Publication Details
- Laboratory Animals, Vol.47(1), pp.66-70
- Publisher
- Royal Society of Medicine Press
- Identifiers
- 991005541892607891
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
33 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1642 Veterinary Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- Zoology
- ESI research areas
- Plant & Animal Science