Journal article
Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial
Intensive Care Medicine, Vol.42(11), pp.1715-1722
2016
Abstract
Purpose
Both anaemia and allogenic red blood cell transfusion are common and potentially harmful in patients admitted to the intensive care unit. Whilst intravenous iron may decrease anaemia and RBC transfusion requirement, the safety and efficacy of administering iron intravenously to critically ill patients is uncertain.
Methods
The multicentre, randomized, placebo-controlled, blinded Intravenous Iron or Placebo for Anaemia in Intensive Care (IRONMAN) study was designed to test the hypothesis that, in anaemic critically ill patients admitted to the intensive care unit, early administration of intravenous iron, compared with placebo, reduces allogeneic red blood cell transfusion during hospital stay and increases the haemoglobin level at the time of hospital discharge.
Results
Of 140 patients enrolled, 70 were assigned to intravenous iron and 70 to placebo. The iron group received 97 red blood cell units versus 136 red blood cell units in the placebo group, yielding an incidence rate ratio of 0.71 [95 % confidence interval (0.43–1.18), P = 0.19]. Overall, median haemoglobin at hospital discharge was significantly higher in the intravenous iron group than in the placebo group [107 (interquartile ratio IQR 97–115) vs. 100 g/L (IQR 89–111),P = 0.02]. There was no significant difference between the groups in any safety outcome.
Conclusions
In patients admitted to the intensive care unit who were anaemic, intravenous iron, compared with placebo, did not result in a significant lowering of red blood cell transfusion requirement during hospital stay. Patients who received intravenous iron had a significantly higher haemoglobin concentration at hospital discharge.
Details
- Title
- Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial
- Authors/Creators
- E. Litton (Author/Creator)S. Baker (Author/Creator)W.N. Erber (Author/Creator)S. Farmer (Author/Creator)J. Ferrier (Author/Creator)C. French (Author/Creator)J. Gummer (Author/Creator)D. Hawkins (Author/Creator)A. Higgins (Author/Creator)A. Hofmann (Author/Creator)B. De Keulenaer (Author/Creator)J. McMorrow (Author/Creator)J.K. Olynyk (Author/Creator)T. Richards (Author/Creator)S. Towler (Author/Creator)R. Trengove (Author/Creator)S. Webb (Author/Creator)
- Publication Details
- Intensive Care Medicine, Vol.42(11), pp.1715-1722
- Publisher
- Springer Verlag
- Identifiers
- 991005544469507891
- Copyright
- © 2016 Springer-Verlag Berlin Heidelberg and ESICM
- Murdoch Affiliation
- Separation Science and Metabolomics Laboratory
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.75 Blood Clotting
- 1.75.324 Transfusion
- Web Of Science research areas
- Critical Care Medicine
- ESI research areas
- Clinical Medicine