Investigating gains in neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol

K.I. Erickson; G.A. Grove; J.M. Burns; C.H. Hillman; A.F. Kramer; E. McAuley; E.D. Vidoni; J.T. Becker; M.A. Butters; K. Gray; H. Huang; J.M. Jakicic; M.I. Kamboh; C. Kang; W.E. Klunk; P. Lee; A.L. Marsland; J. Mettenburg; R.J. Rogers; C.M. Stillman; B.P. Sutton; A. Szabo-Reed; T.D. Verstynen; J.C. Watt; A.M. Weinstein; M.E. Wollam

doi:10.1016/j.cct.2019.105832

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Investigating gains in neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol

Journal article

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Investigating gains in neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol

K.I. Erickson, G.A. Grove, J.M. Burns, C.H. Hillman, A.F. Kramer, E. McAuley, E.D. Vidoni, J.T. Becker, M.A. Butters, K. Gray, …

Contemporary Clinical Trials, Vol.85

2019

DOI: https://doi.org/10.1016/j.cct.2019.105832

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Abstract

Despite the ubiquity of normal age-related cognitive decline there is an absence of effective approaches for improving neurocognitive health. Fortunately, moderate intensity exercise is a promising method for improving brain and cognitive health in late life, but its effectiveness remains a matter of skepticism and debate because of the absence of large, comprehensive, Phase III clinical trials. Here we describe the protocol for such a randomized clinical trial called IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), a study capable of more definitively addressing whether exercise influences cognitive and brain health in cognitively normal older adults. We are conducting a 12-month, multi-site, randomized dose-response exercise trial in 639 cognitively normal adults between 65 and 80 years of age. Participants are randomized to (1) a moderate intensity aerobic exercise condition of 150 min/week (N = 213), (2) a moderate intensity aerobic exercise condition at 225 min/week (N = 213), or (3) a light intensity stretching-and-toning control condition for 150 min/week (N = 213). Participants are engaging in 3 days/week of supervised exercise and two more days per week of unsupervised exercise for 12 months. A comprehensive cognitive battery, blood biomarkers and battery of psychosocial questionnaires is assessed at baseline, 6 and 12-months. In addition, brain magnetic resonance imaging, physiological biomarkers, cardiorespiratory fitness, physical function, and positron emission tomography of amyloid deposition are assessed at baseline and at the 12-month follow-up. The results from this trial could transform scientific-based policy and health care recommendations for approaches to improve cognitive function in cognitively normal older adults.

Details

Title: Investigating gains in neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol
Authors/Creators: K.I. Erickson (Author/Creator) - University of Pittsburgh
G.A. Grove (Author/Creator) - University of Pittsburgh
J.M. Burns (Author/Creator) - University of Kansas Medical Center
C.H. Hillman (Author/Creator) - Northeastern University
A.F. Kramer (Author/Creator) - University of Illinois Urbana-Champaign
E. McAuley (Author/Creator) - University of Illinois Urbana-Champaign
E.D. Vidoni (Author/Creator) - University of Kansas Medical Center
J.T. Becker (Author/Creator) - University of Pittsburgh
M.A. Butters (Author/Creator) - University of Pittsburgh
K. Gray (Author/Creator) - University of Pittsburgh
H. Huang (Author/Creator) - University of Pittsburgh
J.M. Jakicic (Author/Creator) - University of Pittsburgh
M.I. Kamboh (Author/Creator) - University of Pittsburgh
C. Kang (Author/Creator) - University of Pittsburgh
W.E. Klunk (Author/Creator) - University of Pittsburgh
P. Lee (Author/Creator) - University of Kansas Medical Center
A.L. Marsland (Author/Creator) - University of Pittsburgh
J. Mettenburg (Author/Creator) - University of Pittsburgh
R.J. Rogers (Author/Creator) - University of Pittsburgh
C.M. Stillman (Author/Creator) - University of Pittsburgh
B.P. Sutton (Author/Creator) - University of Illinois Urbana-Champaign
A. Szabo-Reed (Author/Creator) - University of Kansas Medical Center
T.D. Verstynen (Author/Creator) - Carnegie Mellon University
J.C. Watt (Author/Creator) - University of Pittsburgh
A.M. Weinstein (Author/Creator) - University of Pittsburgh
M.E. Wollam (Author/Creator) - University of Pittsburgh
Publication Details: Contemporary Clinical Trials, Vol.85
Publisher: Elsevier Inc.
Identifiers: 991005541969207891
Copyright: © 2019 Elsevier Inc.
Murdoch Affiliation: School of Allied Health
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Medicine, Research & Experimental; Pharmacology & Pharmacy
ESI research areas: Clinical Medicine