Journal article
Investigation of the spectroscopic, thermal and electrochemical properties of tris-(glycinato)chromium(III)
ChemistrySelect, Vol.2(5), pp.1950-1958
2017
Abstract
The tris-glycinatochromium(III) complex ([Cr(gly)3]) has been proposed as a nutritional supplement and treatment for Type 2 diabetes. The exact mode of action of this and other Cr(III) supplements is not known but may involve redox reactions with biomolecules. In this study fac-[Cr(gly)3] was synthesized and the electrochemical properties investigated by cyclic voltammetry. The complex undergoes a reversible one electron reduction with E1/2=−0.66 to −0.69 V that is essentially independent of scan rate. Thermal decomposition was explored by differential scanning calorimetry under nonisothermal conditions from 30−1000 °C. Structural parameters obtained from DFT calculations are in good agreement with crystallographic data. The reduced form of the complex has a high-spin quintet electronic configuration due to the small crystal field splitting from the weak π-donor ligands. Both the theoretical calculations and the electrochemical measurements demonstrate that the complex is stable in the anionic form. These results indicate that [Cr(gly)3] can undergo reversible electron transfer, which may play a role in it's biological activity.
Details
- Title
- Investigation of the spectroscopic, thermal and electrochemical properties of tris-(glycinato)chromium(III)
- Authors/Creators
- K.M. Uddin (Author/Creator) - Murdoch UniversityA.M. Habib (Author/Creator) - Tohoku UniversityD.J. Henry (Author/Creator) - Murdoch University
- Publication Details
- ChemistrySelect, Vol.2(5), pp.1950-1958
- Publisher
- Wiley
- Identifiers
- 991005543366607891
- Copyright
- © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.22 Inorganic & Nuclear Chemistry
- 2.22.1258 Catalytic Complexes
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry