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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Iron: An emerging factor in colorectal carcinogenesis
World Journal of Gastroenterology, Vol.16(6), pp.663-672
2010
Abstract
The carcinogenic potential of iron in colorectal cancer (CRC) is not fully understood. Iron is able to undergo reduction and oxidation, making it important in many physiological processes. This inherent redox property of iron, however, also renders it toxic when it is present in excess. Iron-mediated generation of reactive oxygen species via the Fenton reaction, if uncontrolled, may lead to cell damage as a result of lipid peroxidation and oxidative DNA and protein damage. This may promote carcinogenesis through increased genomic instability, chromosomal rearrangements as well as mutations of proto-oncogenes and tumour suppressor genes. Carcinogenesis is also affected by inflammation which is exacerbated by iron. Population studies indicate an association between high dietary iron intake and CRC risk. In this editorial, we examine the link between iron-induced oxidative stress and inflammation on the pathogenesis of CRC.
Details
- Title
- Iron: An emerging factor in colorectal carcinogenesis
- Authors/Creators
- A.C.G. Chua (Author/Creator)B. Klopcic (Author/Creator)I.C. Lawrance (Author/Creator)J.K. Olynyk (Author/Creator)D. Trinder (Author/Creator)
- Publication Details
- World Journal of Gastroenterology, Vol.16(6), pp.663-672
- Publisher
- Baishideng Publishing Group
- Identifiers
- 991005543603507891
- Copyright
- © 2010 Baishideng
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.184 Physiology & Metals
- 1.184.573 Iron Metabolism
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine