Journal article
Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part II. Formation constants with iron(III) and iron(II)
Inorganica Chimica Acta, Vol.170(2), pp.171-176
1990
Abstract
Formation constants for the iron(III) complexes of the orally effective iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and three analogues: pyridoxal benzoyl hydrazone (PBH), 3-hydroxy- isonicotinaldehyde isonicotinoyl hydrazone (IIH) and salicylaldehyde isonicotinoyl hydrazone (SIH), have been determined by a combination of spectrophotometry and potentiometry. All four ligands bind iron(III) strongly giving, at physiological pH 7.4, values of pM (−log[uncomplexed metal]) between 27.7 and 50, comparable to or greater than those for transferrin (25.6) and desferrioxamine B (28.6). The complexation of Fe(II) by PIH has also been studied and has been found to be appreciable but very much weaker than that for Fe(III).
Details
- Title
- Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part II. Formation constants with iron(III) and iron(II)
- Authors/Creators
- L.M. Wis Vitolo (Author/Creator)G.T. Hefter (Author/Creator) - Murdoch UniversityB.W. Clare (Author/Creator) - Murdoch UniversityJ. Webb (Author/Creator) - Murdoch University
- Publication Details
- Inorganica Chimica Acta, Vol.170(2), pp.171-176
- Publisher
- Elsevier BV
- Identifiers
- 991005540127507891
- Copyright
- © 1990 Elsevier B.V.
- Murdoch Affiliation
- School of Mathematical and Physical Sciences
- Language
- English
- Resource Type
- Journal article
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